Open AccessInhibition of high-mobility group box 1 expression by siRNA in rat hepatic stellate cells
Author(s) -
Wensong Ge
Publication year - 2011
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v17.i36.4090
Subject(s) - hmgb1 , hepatic stellate cell , transfection , gene silencing , lipofectamine , downregulation and upregulation , small interfering rna , fibrosis , microbiology and biotechnology , blot , hepatic fibrosis , cell culture , chemistry , biology , cancer research , pathology , medicine , immunology , endocrinology , biochemistry , gene , recombinant dna , inflammation , genetics , vector (molecular biology)
To explore the role of high-mobility group box 1 (HMGB1) protein during liver fibrogenesis and investigate the functional effects of HMGB1 gene silencing in hepatic stellate cells (HSCs) using siRNA.