Open AccessGastric carcinoid in a patient infected withHelicobacter pylori: A new entity?
Author(s) -
Pantelis Antonodimitrakis,
Apostolos V. Tsolakis,
Staffan Welin,
Gordana Kozlovacki,
Kjell Öberg,
Dan Granberg
Publication year - 2011
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v17.i25.3066
Subject(s) - helicobacter pylori , gastrin , gastroenterology , medicine , chronic gastritis , carcinoid tumors , gastritis , stomach , enterochromaffin like cell , cancer , enterochromaffin cell , adenocarcinoma , pathology , secretion , receptor , serotonin
There are four types of gastric carcinoid tumors, classified according to their histology and malignant potential. Only a few cases of carcinoid tumors in patients infected with Helicobacter pylori (H. pylori) have been reported so far. We report a patient infected with H. pylori presenting with a small solitary gastric carcinoid tumor with very low proliferative rate and normal gastrin levels. The tumor was endoscopically removed and the patient received an eradication therapy against H. pylori. No signs of metastatic disease have been found so far during more than 3 year of follow-up. Infection with H. pylori may cause chronic gastritis with normal or elevated gastrin levels, leading to the development of gastric carcinoids by mechanisms unrelated to gastrin. Enterochromaffin-like cell tumors related to a chronic H. pylori infection may be considered as a distinct type of gastric carcinoid tumors.