Open AccessDown-regulation of STAT3 expression by vector-based small interfering RNA inhibits pancreatic cancer growth
Author(s) -
Chen Huang,
Guang Yang,
Tao Jiang,
Jun Cao,
Kai-Wen Huang,
Zhengjun Qiu
Publication year - 2011
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v17.i25.2992
Subject(s) - rna interference , pancreatic cancer , small interfering rna , cancer research , stat3 , small hairpin rna , biology , cell growth , transfection , signal transduction , gene silencing , microbiology and biotechnology , cell culture , apoptosis , cancer , rna , gene knockdown , gene , biochemistry , genetics
To evaluate the effect of RNA interference (RNAi) mediated silence of signal transduction and activation of transcription (STAT)3 on the growth of human pancreatic cancer cells both in vitro and in vivo.