Open AccessAntitumor activity of mutant bacterial cytosine deaminase gene for colon cancer
Author(s) -
Lingxiao Deng,
Jianping Wang,
Zhifu Gui,
Lizong Shen
Publication year - 2011
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v17.i24.2958
Subject(s) - cytosine deaminase , genetic enhancement , transfection , mutant , microbiology and biotechnology , gene delivery , viral vector , biology , cancer research , recombinant dna , gene , biochemistry
To evaluate bacterial cytosine deaminase (bCD) mutant D314A and 5-fluorocytosine (5-FC) for treatment of colon cancer in a mouse model.