Open AccessPAd-shRNA-PTN reduces pleiotrophin of pancreatic cancer cells and inhibits neurite outgrowth of DRG
Author(s) -
Jun Yao,
Min Zhang,
Qingyong Ma,
Zheng Wang,
Liancai Wang,
Dong Zhang
Publication year - 2011
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v17.i21.2667
Subject(s) - pleiotrophin , neurite , dorsal root ganglion , gene knockdown , immunocytochemistry , blot , small hairpin rna , pancreatic cancer , gene silencing , microbiology and biotechnology , cancer research , in vitro , cell culture , chemistry , biology , pathology , cancer , medicine , spinal cord , receptor , gene , neuroscience , growth factor , biochemistry , genetics
To investigate the silencing effects of pAd-shRNA-pleiotrophin (PTN) on PTN in pancreatic cancer cells, and to observe the inhibition of pAd-shRNA-PTN on neurite outgrowth from dorsal root ganglion (DRG) neurons in vitro.