Open AccessNeoadjuvant sorafenib combined with gemcitabine plus oxaliplatin in advanced hepatocellular carcinoma
Author(s) -
Nicolas Williet,
Olivier Dubreuil,
Tarek Boussaha,
Isabelle Trouilloud,
Bruno Landi,
M. Housset,
Muriel Botti,
Philippe Rougier,
Jacques Belghiti,
Julien Taı̈eb
Publication year - 2011
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v17.i17.2255
Subject(s) - sorafenib , oxaliplatin , gemcitabine , hepatocellular carcinoma , medicine , oncology , lymph node metastasis , carcinoma , metastasis , chemotherapy , colorectal cancer , cancer
This paper reports the first case of a patient with hepatocellular carcinoma with lymph node metastasis treated by sorafenib combined with gemcitabine plus oxaliplatin, with a partial response and normalization of α fetoprotein, which allowed curative surgery. The potential synergy between these three drugs needs to be confirmed, and is currently being investigated in a randomized phase II trial.