Neoadjuvant sorafenib combined with gemcitabine plus oxaliplatin in advanced hepatocellular carcinoma | Zendy

Nicolas Williet | Zendy

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Neoadjuvant sorafenib combined with gemcitabine plus oxaliplatin in advanced hepatocellular carcinoma

Author(s) -

Nicolas Williet

Publication year - 2011

Publication title -

world journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 155

eISSN - 2219-2840

pISSN - 1007-9327

DOI - 10.3748/wjg.v17.i17.2255

Subject(s) - sorafenib , oxaliplatin , gemcitabine , hepatocellular carcinoma , medicine , oncology , lymph node metastasis , carcinoma , metastasis , chemotherapy , colorectal cancer , cancer

This paper reports the first case of a patient with hepatocellular carcinoma with lymph node metastasis treated by sorafenib combined with gemcitabine plus oxaliplatin, with a partial response and normalization of α fetoprotein, which allowed curative surgery. The potential synergy between these three drugs needs to be confirmed, and is currently being investigated in a randomized phase II trial.

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