Open AccessIncreasing the frequency of CIK cells adoptive immunotherapy may decrease risk of death in gastric cancer patients
Author(s) -
Jingting Jiang,
Yueping Shen,
Changping Wu,
Yueyong Zhu,
Wenxiang Wei,
Lüjun Chen,
Xiao Zheng,
Jing Sun,
Binfeng Lu,
Xueguang Zhang
Publication year - 2010
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v16.i48.6155
Subject(s) - medicine , cytokine induced killer cell , immunotherapy , adoptive immunotherapy , cancer , adoptive cell transfer , oncology , hazard ratio , chemotherapy , immunology , survival analysis , proportional hazards model , gastroenterology , confidence interval , t cell , antigen , immune system , cd8 , cd3
to analyze the correlation between cytokine-induced killer (cik) cells adoptive immunotherapy and cancer-related death in gastric cancer patients. methods: One hundred and fifty-six gastric cancer patients after operation at the Third Affiliated Hospital of Soochow University were enrolled in this study. Their clinical data including demographic characteristics, operation time, tumor size, pathological type and staging, tumor metastasis, outcome of chemotherapy or CIK cells adoptive immunotherapy, survival time or time of death were collected with a standard structured questionnaire. Kaplan-Meier method was used to estimate the median survival time, and the 2- and 5- year survival rates. Hazard risk (HR) and 95% confidence interval (95% CI) of CIK cells adoptive immunotherapy for gastric cancer were calculated using the two-stage time-dependent covariates Cox model.