Open AccessAcute necrotizing pancreatitis as first manifestation of primary hyperparathyroidism
Author(s) -
J Lenz,
Jimmy M Jacobs,
Bart Op de Beeck,
Ivan Huyghe,
Paul Pelckmans,
Tom G. Moreels
Publication year - 2010
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v16.i23.2959
Subject(s) - medicine , acute pancreatitis , parathyroid adenoma , primary hyperparathyroidism , pancreatitis , hyperparathyroidism , adenoma , pancreatic pseudocyst , pathophysiology , surgery , gastroenterology , general surgery
We report the case of a female patient with severe acute necrotizing pancreatitis associated with hypercalcemia as first manifestation of primary hyperparathyroidism caused by a benign parathyroid adenoma. Initially the acute pancreatitis was treated conservatively. The patient subsequently underwent surgical resection of the parathyroid adenoma and surgical clearance of a large infected pancreatic pseudocyst. Although the association of parathyroid adenoma-induced hypercalcemia and acute pancreatitis is a known medical entity, it is very uncommon. The pathophysiology of hypercalcemia-induced acute pancreatitis is therefore not well known, although some mechanisms have been proposed. It is important to treat the provoking factor. Therefore, the cause of hypercalcemia should be identified early. Surgical resection of the parathyroid adenoma is the ultimate therapy.