Open AccessCXCR4 antagonist AMD3100 attenuates colonic damage in mice with experimental colitis
Author(s) -
Xianming Xia,
Fangyu Wang,
Wenli Xu,
Zhenkai Wang,
Jiong Liu,
Youke Lu,
Xinxin Jin,
Heng Lu,
Yanjie Shen
Publication year - 2010
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v16.i23.2873
Subject(s) - colitis , proinflammatory cytokine , tumor necrosis factor alpha , cytokine , inflammation , chemokine , myeloperoxidase , chemistry , pathology , immunology , medicine
To investigate the effects of the chemokine stromal cell-derived factor-1 (CXCL12) receptor (CXCR4) antagonist AMD3100 on colonic inflammation and epithelial barrier in dextran sulfate sodium (DSS)-induced colitis in mice.