Open AccessJAK-STAT pathway in carcinogenesis: Is it relevant to cholangiocarcinoma progression?
Author(s) -
О. В. Смирнова,
T. Y. Ostroukhova,
Roman L. Bogorad
Publication year - 2007
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v13.i48.6478
Subject(s) - carcinogenesis , stat , cancer research , signal transduction , jak stat signaling pathway , cytokine , biology , interleukin 6 , medicine , immunology , stat3 , cancer , microbiology and biotechnology , receptor tyrosine kinase
The features of JAK-STAT signaling in liver cells are discussed in the current review. The role of this signaling cascade in carcinogenesis is accentuated. The possible involvement of this pathway and alteration of its elements are compared for normal cholangiocytes, cholangiocarcinoma predisposition and development. Prolactin and interleukin-6 are described in detail as the best studied examples. In addition, the non-classical nuclear translocation of cytokine receptors is discussed in terms of its possible implication to cholangiocarcinoma development.