Open AccessPancreatic endocrine and exocrine changes in celiac disease
Author(s) -
Hugh James Freeman
Publication year - 2007
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v13.i47.6344
Subject(s) - endocrine system , pancreas , medicine , diabetes mellitus , gastroenterology , disease , concomitant , exocrine pancreas , exocrine pancreatic insufficiency , pancreatic disease , pancreatitis , malnutrition , endocrinology , hormone
Although there is a great deal of information on celiac disease and associated involvement of other non-intestinal sites, data on concomitant changes in the structure and function of the pancreas is limited. The present review critically examines pancreatic endocrine changes that have been well documented in the literature, including insulin-dependent diabetes mellitus. Pancreatic exocrine alterations may also occur, and if severe, marked malnutrition with pancreatic failure and ductal calcification have been observed. Finally, other pancreatic disorders have been recorded with celiac disease.