Open AccessRe-expression of methylation-induced tumor suppressor gene silencing is associated with the state of histone modification in gastric cancer cell lines
Author(s) -
Chao Meng,
Xuyou Zhu,
Peng Guo,
DongQiu Dai
Publication year - 2007
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v13.i46.6166
Subject(s) - cancer epigenetics , trichostatin a , dna methylation , biology , microbiology and biotechnology , histone , epigenetics , histone methylation , cancer research , histone h3 , epigenomics , chromatin immunoprecipitation , histone h2a , methylation , histone methyltransferase , promoter , gene expression , histone deacetylase , genetics , gene
To identify the relationship between DNA hyper-methylation and histone modification at a hyperme-thylated, silenced tumor suppressor gene promoter in human gastric cancer cell lines and to elucidate whether alteration of DNA methylation could affect histone modification.