Open AccessIdentification of Lynch syndrome: How should we proceed in the 21stcentury?
Author(s) -
Antoni Castells,
Francesc Balaguer,
Sergi Castellví–Bel,
Victòria Gonzalo,
Teresa Ocaña
Publication year - 2007
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v13.i33.4413
Subject(s) - lynch syndrome , colorectal cancer , colonoscopy , medicine , incidence (geometry) , cancer , oncology , dna mismatch repair , physics , optics
Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC), is the most common form of hereditary colorectal cancer. Although great advances in the understanding of its molecular basis have taken place in the last decade, optimal selection of individuals for HNPCC genetic testing remains controversial. This is especially relevant since colonoscopy has been proven effective for reducing colorectal cancer incidence and mortality in individuals at-risk for this disorder. In this manuscript, we summarize the most significant contributions to this important issue that have appeared in the last few years.