Open AccessAbnormal endogenous pain modulation and somatic and visceral hypersensitivity in female patients with irritable bowel syndrome
Author(s) -
Clive H. WilderSmith
Publication year - 2007
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v13.i27.3699
Subject(s) - irritable bowel syndrome , medicine , visceral pain , stimulation , sensitization , somatic cell , visual analogue scale , nociception , gastroenterology , anesthesia , immunology , receptor , biochemistry , gene , chemistry
To investigate the role of endogenous pain modulatory mechanisms in the central sensitization implicated by the visceral hypersensitivity demonstrated in patients with irritable bowel syndrome (IBS). Dysfunction of modulatory mechanisms would be expected to also result in changes of somatic sensory function.