Open AccessIn situ tumor vaccination with adenovirus vectors encoding measles virus fusogenic membrane proteins and cytokines
Author(s) -
Dennis Hoffmann,
Wibke Bayer,
Oliver Wildner
Publication year - 2007
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v13.i22.3063
Subject(s) - measles virus , biology , ctl* , oncolytic virus , microbiology and biotechnology , viral vector , cancer research , immune system , t cell , virology , immunology , cd8 , vaccination , measles , biochemistry , gene , recombinant dna
To evaluate whether intratumoral expression of measles virus fusogenic membrane glycoproteins H and F (MV-FMG), encoded by an adenovirus vector Ad.MV-H/F, alone or in combination with local coexpression of cytokines (IL-2, IL-12, IL-18, IL-21 or GM-CSF), can serve as a platform for inducing tumor-specific immune responses in colon cancer.