Open AccessEthanol induced mitochondria injury and permeability transition pore opening: Role of mitochondria in alcoholic liver disease
Author(s) -
Ming Yan,
Pinghua Zhu,
Huimin Liu,
Haitao Zhang,
Li Liu
Publication year - 2007
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v13.i16.2352
Subject(s) - mitochondrion , mitochondrial permeability transition pore , membrane potential , alcoholic liver disease , calcium , chemistry , intracellular , biology , biochemistry , biophysics , microbiology and biotechnology , medicine , apoptosis , programmed cell death , cirrhosis , organic chemistry
To observe changes of mitochondria and investigate the effect of ethanol on mitochondrial perme-ability transition pore (PTP), mitochondrial membrane potential (MMP, Delta psi m) and intracellular calcium concentration in hepatocytes by establishing an animal model of alcoholic liver disease (ALD).