Open AccessUpdate on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicenter study
Author(s) -
Sophie DesplatJégo,
Catherine Johanet,
Aurélie Escande,
Joëlle Goetz,
Nicole Fabien,
NilsOlivier Olsson,
Éric Ballot,
J. Sarles,
Jean-Jacques Baudon,
J. C. Grimaud,
M. Veyrac,
P. Chamouard,
RenéLouis Humbel
Publication year - 2007
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v13.i16.2312
Subject(s) - antibody , immunofluorescence , indirect immunofluorescence , medicine , immunology , autoantibody , inflammatory bowel diseases , exocrine pancreas , inflammatory bowel disease , pancreas , pathology , disease
Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn's disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD.