Open AccessDown-regulation of Bcl-XLby RNA interference suppresses cell growth and induces apoptosis in human esophageal cancer cells
Author(s) -
Yi Xie,
Tang En-jie,
Zhang Da-rong,
Biao Ren
Publication year - 2006
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v12.i46.7472
Subject(s) - small interfering rna , transfection , lipofectamine , apoptosis , rna interference , esophageal cancer , microbiology and biotechnology , cancer cell , biology , cell , cancer research , cell growth , vector (molecular biology) , expression vector , cancer , cell culture , rna , gene , biochemistry , genetics , recombinant dna
To determine the inhibitory effect of the vector-generated small interfering RNAs (siRNAs) on the expression of the Bcl-X(L) gene in established human esophageal cancer cells, and to investigate the effect of the Bcl-X(L) siRNAs on cell growth and apoptosis in esophageal cancer cells.