Open AccessIdentification of specific genes and pathways involved in NSAIDs-induced apoptosis of human colon cancer cells
Author(s) -
Richard H. Huang,
Jianyuan Chai,
Andrzej S. Tarnawski
Publication year - 2006
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v12.i40.6446
Subject(s) - apoptosis , programmed cell death , microbiology and biotechnology , tunel assay , intrinsic apoptosis , biology , cancer research , signal transduction , caspase , genetics
To study whether indomethacin (IND), a nonselective cyclooxygenase (COX) inhibitor or NS-398 (NS), a COX-2-selective inhibitor, induces apoptosis in human colon cancer cells and which apoptosis-related genes and pathways are involved.