Open AccessAttenuation of gastric mucosal inflammation induced by aspirin through activation of A2Aadenosine receptor in rats
Author(s) -
Masaru Odashima,
Michiro Otaka,
Mario Jin,
Kyoji Komatsu,
Isao Wada,
Youhei Horikawa,
Tamotsu Matsuhashi,
Natsumi Hatakeyama,
Jinko Oyaké,
Reina Ohba,
Sumio Watanabe,
Joel Linden
Publication year - 2006
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v12.i4.568
Subject(s) - aspirin , agonist , gastric mucosa , myeloperoxidase , medicine , ulcer index , adenosine , proinflammatory cytokine , pharmacology , inflammation , stomach , receptor , chemistry , endocrinology
To determine whether a specific adenosine A(2A) receptor agonist (ATL-146e) can ameliorate aspirin-induced gastric mucosal lesions in rats, and reduce neutrophil accumulation and production of pro-inflammatory cytokines.