Open AccessAcute coronary syndrome after infliximab therapy in a patient with Crohn’s disease
Author(s) -
Vasilios Panteris,
Anna Perdiou,
Vasilios G. Tsirimpis,
D.G. Karamanolis
Publication year - 2006
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v12.i38.6235
Subject(s) - infliximab , medicine , crohn's disease , disease , refractory (planetary science) , adverse effect , intensive care medicine , drug , pharmacology , physics , astrobiology
Infliximab is a potent anti-TNF antibody, which is used with great success in Crohn's disease patients. Since its release in clinical practice, several adverse reactions have been observed. The interest in possible consequences of its administration is still high because of the recent introduction of the drug for the long-term maintenance therapy of refractory luminal and fistulizing Crohn's disease. We present a case of acute coronary syndrome (non-STEMI) in a patient with corticoid resistant Crohn's disease after his first dose of infliximab. By reviewing the scant articles that exist in the literature on this topic we made an effort to delineate the possible mechanisms of this phenomenon.