Open AccessProlonged exposure of colon cancer cells to the epidermal growth factor receptor inhibitor gefitinib (Iressa™) and to the antiangiogenic agent ZD6474: Cytotoxic and biomolecular effects
Author(s) -
Amalia Azzariti,
Letizia Porcelli,
Jian Xu,
G. Simone,
Angelo Paradiso
Publication year - 2006
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v12.i32.5140
Subject(s) - gefitinib , epidermal growth factor receptor , cytotoxic t cell , cancer research , epidermal growth factor , colorectal cancer , cell growth , growth inhibition , egfr inhibitors , growth factor receptor , pharmacology , chemistry , cancer , medicine , receptor , in vitro , biochemistry
To analyze the biological effects of prolonged in vitro exposure of HT-29 and LoVo colon cancer cell lines to gefitinib (Iressa), an inhibitor of epidermal growth factor receptor (EGFR) activity, and ZD6474, an inhibitor of both KDR and EGFR activities.