Open AccessObstructive jaundice leads to accumulation of oxidized low density lipoprotein in human liver tissue
Author(s) -
Mustafa Cömert,
Yücel Üstündağ,
İshak Özel Tekin,
Banu Doğan Gün,
Figen Barut
Publication year - 2006
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v12.i31.5094
Subject(s) - obstructive jaundice , oxidative stress , jaundice , lipoprotein , immune system , medicine , liver tissue , bile duct , low density lipoprotein , chemistry , oxidative phosphorylation , endocrinology , biochemistry , immunology , cholesterol
Oxidized low density lipoprotein (ox-LDL) molecule is one of the most important modified lipoproteins produced during the oxidative stress. Modified lipoproteins have been defined as being part of the immune inflammatory mechanisms in association with oxidant stress. We have reported the accumulation of ox-LDL in Balb/c mice liver after bile duct ligation previously. Here, we investigated this finding in human beings with obstructive jaundice. Our study demonstrates that obstructive jaundice results in tremendous accumulation of ox-LDL in the liver tissue of patients.