Open AccessAdministration of granulocyte colony stimulating factor after liver transplantation leads to an increased incidence and severity of ischemic biliary lesions in the rat model
Author(s) -
Olaf Dirsch,
Haidong Chi,
Yuan Ji,
Yue Gu,
Christoph E. Broelsch,
Uta Dahmen
Publication year - 2006
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v12.i31.5021
Subject(s) - medicine , liver transplantation , granulocyte colony stimulating factor , transplantation , perfusion , granulocyte , ischemia , pathology , gastroenterology , chemotherapy
Recently it has been reported that granulocyte colony stimulating factor (G-CSF) can induce hypercoagulability in healthy bone marrow donors. It is conceivable that the induction of a prothrombotic state in a recipient of an organ graft with already impaired perfusion might cause further deterioration in the transplanted organ. This study evaluated whether G-CSF treatment worsens liver perfusion following liver transplantation in the rat model.