Open AccessPost-transcriptional regulation of vascular endothelial growth factor: Implications for tumor angiogenesis
Author(s) -
Peter S. Yoo,
Abby L. Mulkeen,
Charles Cha
Publication year - 2006
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v12.i31.4937
Subject(s) - angiogenesis , vascular endothelial growth factor , messenger rna , biology , rna interference , vascular endothelial growth factor a , cancer research , transcriptional regulation , transcription factor , gene isoform , microbiology and biotechnology , untranslated region , rna , vegf receptors , genetics , gene
Vascular endothelial growth factor (VEGF) is a potent secreted mitogen critical for physiologic and tumor angiogenesis. Regulation of VEGF occurs at several levels, including transcription, mRNA stabilization, translation, and differential cellular localization of various isoforms. Recent advances in our understanding of post-transcriptional regulation of VEGF include identification of the stabilizing mRNA binding protein, HuR, and the discovery of internal ribosomal entry sites in the 5'UTR of the VEGF mRNA. Monoclonal anti-VEGF antibody was recently approved for use in humans, but suffers from the need for high systemic doses. RNA interference (RNAi) technology is being used in vitro and in animal models with promising results. Here, we review the literature on post-transcriptional regulation of VEGF and describe recent progress in targeting these mechanisms for therapeutic benefit.