Open AccessDifferential effects on apoptosis induction in hepatocyte lines by stable expression of hepatitis B virus X protein
Author(s) -
Nicola Fiedler,
Ellen Quant,
Ludger Fink,
Jianguang Sun,
Ralph Schuster,
Wolfram H. Gerlich,
Stephan Schaefer
Publication year - 2006
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v12.i29.4673
Subject(s) - hbx , apoptosis , cell culture , hepatocyte , microbiology and biotechnology , biology , transfection , cancer research , chemistry , in vitro , biochemistry , genetics
Hepatitis B virus protein X (HBx) has been shown to be weakly oncogenic in vitro. The transforming activities of HBx have been linked with the inhibition of several functions of the tumor suppressor p53. We have studied whether HBx may have different effects on p53 depending on the cell type.