Open AccessMechanism for Src activation by the CCK2 receptor: Patho-physiological functions of this receptor in pancreas
Author(s) -
Audrey Ferrand,
Sébastien Vatinel,
Aline KowalskiChauvel,
Bertrand Castro,
Chantal Escrieut,
Daniel Fourmy,
Marlène Dufresne,
Catherine Seva
Publication year - 2006
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v12.i28.4498
Subject(s) - mapk/erk pathway , cholecystokinin b receptor , proto oncogene tyrosine protein kinase src , microbiology and biotechnology , biology , receptor , signal transduction , cell growth , cholecystokinin , cancer research , chemistry , biochemistry
To investigate in vivo, whether CCK2 receptors (CCK2R) regulate proteins known to play a crucial role in cell proliferation and cancer development and analyse in vitro the molecular mechanisms that lead to Src activation; in particular, to identify the domains within the CCK2R sequence that are implicated in this activation.