Open AccessA functional variant in the CD209 promoter is associated with DQ2-negative celiac disease in the Spanish population
Author(s) -
Concepción Núñez,
Blanca Rueda,
Alfonso Martínez,
Carlos Maluenda,
Isabel Polanco,
Li-na Ma,
Eduardo Ortega,
Esther Mancebo Sierra,
Emilio G. de la Concha,
Elena Urcelay,
Javier Martín
Publication year - 2006
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v12.i27.4397
Subject(s) - genotyping , biology , allele , human leukocyte antigen , immunology , population , genetic predisposition , immune system , genetics , genotype , gene , antigen , medicine , environmental health
To address the role of CD209 in celiac disease (CD) patients. Non-human leukocyte antigen (HLA) genetic factors in CD predisposition are poorly understood, and environmental factors like infectious pathogens may play a role. CD209 is a dendritic and macrophage surface molecule involved in pathogen recognition and immune activation. Recently, a functional variant in the promoter of the CD209 gene (-336A/G) has been shown to affect the transcriptional CD209 activity in vitro and it has been associated with a higher susceptibility to/or severity of infection.