Open AccessAlphastatin downregulates vascular endothelial cells sphingosine kinase activity and suppresses tumor growth in nude mice bearing human gastric cancer xenografts
Author(s) -
Lin Chen,
Tao Li,
Rong Li,
Bo Wei,
Zhiguang Peng
Publication year - 2006
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v12.i26.4130
Subject(s) - matrigel , angiogenesis , in vivo , neovascularization , cancer research , nude mouse , cancer , vascular endothelial growth factor , mtt assay , medicine , pathology , biology , microbiology and biotechnology , in vitro , biochemistry , vegf receptors
To investigate whether alphastatin could inhibit human gastric cancer growth and furthermore whether sphingosine kinase (SPK) activity is involved in this process.