Open AccessClinical and genetic characteristics of Chinese hereditary nonpolyposis colorectal cancer families
Author(s) -
Xulin Wang,
Ying Yuan,
Suzhan Zhang,
Sheng Cai,
Yanqin Huang,
Jiang Qiang,
Shu Zheng
Publication year - 2006
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v12.i25.4074
Subject(s) - colorectal cancer , frameshift mutation , denaturing high performance liquid chromatography , germline mutation , missense mutation , genetics , cancer , medicine , dna mismatch repair , germline , nonsense mutation , proband , mutation , oncology , biology , gene
To analyze the clinical characteristics of Chinese hereditary nonpolyposis colorectal cancer (HNPCC) families and to screen the germline mutations of human mismatch repair genes hMLH1 and hMSH2 in the probands.