Open AccessDefensive nature of Sargassum polycystum (Brown alga) against acetaminophen-induced toxic hepatitis in rats: Role of drug metabolizing microsomal enzyme system, tumor necrosis factor-α and fate of liver cell structural integrity
Author(s) -
Hanumantha Rao Balaji Raghavendran,
Arumugam Sathivel,
Thiruvengadam Devaki
Publication year - 2006
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v12.i24.3829
Subject(s) - acetaminophen , liver injury , cytochrome p450 , tumor necrosis factor alpha , endocrinology , microsome , pharmacology , medicine , chemistry , biochemistry , enzyme
To assess the defensive nature of Sargassum polycystum (S. polycystum) (Brown alga) against acetaminophen (AAP)-induced changes in drug metabolizing microsomal enzyme system, tumor necrosis factor (TNF-alpha) and fine structural features of the liver during toxic hepatitis in rats.