Open AccessCausal role ofHelicobacter pyloriinfection in gastric cancer
Author(s) -
Takafumi Ando,
Yasuyuki Goto,
Osamu Maeda,
Osamu Watanabe,
Kazuhiro Ishiguro,
Hidemi Goto
Publication year - 2006
Publication title -
world journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v12.i2.181
Subject(s) - helicobacter pylori , cancer , carcinogenesis , atrophic gastritis , gastritis , gastroenterology , medicine , cancer prevention , immunology
Gastric cancer is the second most frequent cancer in the world, accounting for a large proportion of all cancer cases in Asia, Latin America, and some countries in Europe. Helicobacter pylori (H pylori) is regarded as playing a specific role in the development of atrophic gastritis, which represents the most recognized pathway in multistep intestinal-type gastric carcinogenesis. Recent studies suggest that a combination of host genetic factors, bacterial virulence factors, and environmental and lifestyle factors determine the severity of gastric damage and the eventual clinical outcome of H pylori infection. The seminal discovery of H pylori as the leading cause of gastric cancer should lead to effective eradication strategies. Prevention of gastric cancer requires better screening strategies to identify candidates for eradication.