Open AccessGastro-protective action of lafutidine mediated by capsaicin-sensitive afferent neurons without interaction with TRPV1 and involvement of endogenous prostaglandins
Author(s) -
Kazuhiro Fukushima,
Yoko Aoi,
Shinichi Kato,
Koji Takeuchi
Publication year - 2006
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v12.i19.3031
Subject(s) - capsaicin , trpv1 , chemistry , capsazepine , pharmacology , endogeny , receptor , antagonist , receptor antagonist , endocrinology , medicine , transient receptor potential channel , biochemistry
Lafutidine, a histamine H2 receptor antagonist, exhibits gastro-protective action mediated by capsaicin-sensitive afferent neurons (CSN). We compared the effect between lafutidine and capsaicin, with respect to the interaction with endogenous prostaglandins (PG), nitric oxide (NO) and the afferent neurons, including transient receptor potential vanilloid subtype 1 (TRPV1).