Open AccessOxygen radical formation does not have an impact in the treatment of severe acute experimental pancreatitis using free cellular hemoglobin
Author(s) -
Helge Kleinhans,
Oliver Mann,
Paulus Schurr,
Jussuf T. Kaifi,
Bente Hansen,
Jakob R. Izbicki,
Tim Strate
Publication year - 2006
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v12.i18.2914
Subject(s) - lipid peroxidation , malondialdehyde , pancreatitis , acute pancreatitis , microcirculation , hemoglobin , glutathione , medicine , endocrinology , chemistry , biochemistry , oxidative stress , enzyme
Microcirculatory dysfunction and free oxygen radicals are important factors in the pathogenesis of severe acute pancreatitis. Additional oxygen delivery might enhance lipid peroxidation but may also improve pancreatic microcirculation. This study assesses the effect of free cellular bovine hemoglobin on the formation of oxygen radicals and microcirculation in a rodent model of severe acute pancreatitis.