Open AccessUsefulness of liver infiltrating CD86-positive mononuclear cells for diagnosis of autoimmune hepatitis
Author(s) -
Kazutaka Kurokohchi
Publication year - 2006
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v12.i16.2523
Subject(s) - cd86 , peripheral blood mononuclear cell , cd80 , autoimmune hepatitis , immune system , immunology , medicine , hepatitis , liver disease , immune tolerance , t cell , biology , cytotoxic t cell , cd40 , in vitro , biochemistry
Although the pathogenic mechanism underlying autoimmune hepatitis (AIH) remains unclear, the immune system is thought to be critical for the progression of the disease. Cellular immune responses may be linked to the hepatocellular damage in AIH. Recently, much attention has been focused on the critical functions of costimulatory molecules expressed on mononuclear cells in the generation of effective T cell-mediated immune responses. Analysis of costimulatory molecule expressed on mononuclear cells from the patients with AIH may give us insight into the pathogenic mechanism of hepatocellular damage in AIH.