Open AccessNovel susceptibility genes in inflammatory bowel disease
Author(s) -
Colin Noble,
Elaine R. Nimmo,
Daniel R. Gaya,
Richard K. Russell,
Jack Satsangi
Publication year - 2006
Publication title -
world journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v12.i13.1991
Subject(s) - candidate gene , inflammatory bowel disease , genome wide association study , ulcerative colitis , disease , biology , gene , gene expression profiling , pathogenesis , genetics , genetic association , computational biology , bioinformatics , immunology , medicine , gene expression , single nucleotide polymorphism , genotype , pathology
The inflammatory bowel disease, Crohn's disease and ulcerative colitis, are polygenic disorders with important environmental interactions. To date, the most widely adopted approach to identifying susceptibility genes in complex diseases has involved genome wide linkage studies followed by studies of positional candidate genes in loci of interest. This review encompasses data from studies into novel candidate genes implicated in the pathogenesis of inflammatory bowel disease. Novel techniques to identify candidate genes-genome wide association studies, yeast-two hybrid screening, microarray gene expression studies and proteomic profiling, are also reviewed and their potential role in unravelling the pathogenesis of inflammatory bowel disease are discussed.