Open AccessGlycine-extended gastrin activates two independent tyrosine-kinases in upstream of p85/p110 phosphatidylinositol 3-kinase in human colonic tumour cells
Author(s) -
Audrey Ferrand,
Aline KowalskiChauvel,
Julie Pannequin,
Bertrand Castro,
Daniel Fourmy,
Marlène Dufresne,
Catherine Seva
Publication year - 2006
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v12.i12.1859
Subject(s) - proto oncogene tyrosine protein kinase src , kinase , phosphatidylinositol , tyrosine kinase , pi3k/akt/mtor pathway , cancer research , cell growth , signal transduction , receptor tyrosine kinase , chemistry , microbiology and biotechnology , p110α , tyrosine phosphorylation , tyrosine , biology , biochemistry
To investigate whether Src, JAK2 and phosphatidylinositol 3-kinase (PI3K) pathways are involved in the proliferation of human colonic tumour cells induced by glycine-extended gastrin (G-gly), the precursor of the mature amidated gastrin and to elucidate the molecular interaction between these three kinases in response to this peptide.