Open AccessSpontaneous regression of hepatic inflammatory pseudotumor with primary biliary cirrhosis: Case report and literature review
Author(s) -
Hiroshi Koide,
Ken Sato,
Toshio Fukusato,
Kenji Kashiwabara,
Noriaki Sunaga,
Takafumi Tsuchiya,
Saeko Morino,
Naondo Sohara,
Satoru Kakizaki,
Hitoshi Takagi,
Masatomo Mori
Publication year - 2006
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v12.i10.1645
Subject(s) - primary biliary cirrhosis , inflammatory pseudotumor , medicine , etiology , lesion , pathology , biliary cirrhosis , gastroenterology , disease , autoimmune disease
Hepatic inflammatory pseudotumor (IPT) is a rare benign non-neoplastic lesion characterized by proliferating fibrous tissue infiltrated by inflammatory cells. The exact etiology of IPT remains unclear. Although the association of IPT with systemic inflammatory disorders has been well established, a specific relationship with cholangitis is distinctly rare. We report a case of spontaneous regression of hepatic IPT with primary biliary cirrhosis (PBC). To date, only two cases of IPT with PBC have been reported. In our case, however, IPT developed during the course of improvement of cholangitis of PBC induced by effective treatment, differing from two previously reported cases. Our case indicates that the development of IPT does not also relate to the activity of cholangitis and/or hyper gamma-globulinemia, since our case was confirmed radiologically to be free of IPT when biliary enzymes and immunoglobulins were much higher than the corresponding values on admission. Comparison of our case with the two previously reported cases suggests that IPT occurring with PBC does not represent the same disease entity or be a bystander for PBC.