Open AccessCpG oligodeoxynucleotides inhibit tumor growth and reverse the immunosuppression caused by the therapy with 5-fluorouracil in murine hepatoma
Author(s) -
Xian-Song Wang,
Zhonghua Sheng,
Yuhua Ruan,
Guang Yang,
Mei Yang
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i8.1220
Subject(s) - cpg oligodeoxynucleotide , immunosuppression , medicine , subcutaneous injection , cpg site , microbiology and biotechnology , pharmacology , immunology , chemistry , biology , biochemistry , gene expression , dna methylation , gene
To investigate the effect of CpG-containing oligodeoxynucleotides (CpG ODN) alone or in combination with the chemotherapeutic agent 5-fluorouracil (5-FU) on tumor growth and whether CpG ODN can reverse the immunosuppression caused by the chemotherapy with 5-FU in murine hepatoma model.