Open AccessAlterations of mast cells and TGF-β1 on the silymarin treatment for CCl4-induced hepatic fibrosis
Author(s) -
DaHee Jeong,
Gi-Ppeum Lee,
Won–Il Jeong,
Sun-Hee Do,
Hea-Eun Yang,
DongWei Yuan,
Ho-Yong Park,
KyuJong Kim,
KyuShik Jeong
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i8.1141
Subject(s) - hepatic stellate cell , hepatic fibrosis , cirrhosis , fibrosis , inflammation , kupffer cell , mast cell , fibroblast , chemistry , lipid peroxidation , medicine , endocrinology , immunology , oxidative stress , biochemistry , in vitro
Silymarin is a potent antioxidant, antiinflammatory and anti-fibrogenic agent in the liver, which is mediated by alteration of hepatic Kupffer cell function, lipid peroxidation, and collagen production. Especially, in hepatic fibrogenesis, mast cells are expressed in chronic inflammatory conditions, and promote fibroblast growth and stimulate production of the extracellular matrix by hepatic stellate cells.