Open AccessA nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis
Author(s) -
Tamás Letoha,
Csaba Somlai,
Tamás Takács,
Annamária Szabolcs,
K. Jármay,
Zoltán Rakonczay,
Péter Hegyi,
I Varga,
József Kaszaki,
István A. Krizbai,
Imre Boros,
E. Duda,
Erzsébet Kúsz,
Botond Penke
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i7.990
Subject(s) - acute pancreatitis , cholecystokinin , pancreatitis , acinar cell , medicine , endocrinology , lipid peroxidation , glutathione , oxidative stress , peptide , chemistry , biochemistry , enzyme , receptor
To assess the effect of our novel cell-permeable nuclear factor-kappaB (NF-kappaB) inhibitor peptide PN50 in an experimental model of acute pancreatitis. PN50 was produced by conjugating the cell-penetrating penetratin peptide with the nuclear localization signal of the NF-kappaB p50 subunit.