Inhibitory effect of fluvastatin on ileal ulcer formation in rats induced by nonsteroidal antiinflammatory drug | Zendy

Mari Hagiwara | Zendy

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Inhibitory effect of fluvastatin on ileal ulcer formation in rats induced by nonsteroidal antiinflammatory drug

Author(s) -

Mari Hagiwara

Publication year - 2005

Publication title -

world journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 155

eISSN - 2219-2840

pISSN - 1007-9327

DOI - 10.3748/wjg.v11.i7.1040

Subject(s) - fluvastatin , pravastatin , atorvastatin , hmg coa reductase , pharmacology , reductase , pitavastatin , hydroxymethylglutaryl coa reductase , lipid peroxidation , chemistry , medicine , statin , cholesterol , enzyme , biochemistry , simvastatin

Nonsteroidal anti-inflammatory drugs (NSAIDs) cause gastrointestinal damage as one of their side effects in humans and experimental animals. Lipid peroxidation plays an important role in NSAID-induced ulceration. The aim of this study was to investigate the inhibitory effect of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors on the ulceration in small intestines of rats.

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