Open AccessInhibitory effect of fluvastatin on ileal ulcer formation in rats induced by nonsteroidal antiinflammatory drug
Author(s) -
Mari Hagiwara,
Keiko Kataoka,
Hideki Arimochi,
Tomomi Kuwahara,
Haruyuki Nakayama,
Yoshinari Ohnishi
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i7.1040
Subject(s) - fluvastatin , pravastatin , atorvastatin , hmg coa reductase , pharmacology , reductase , pitavastatin , hydroxymethylglutaryl coa reductase , lipid peroxidation , chemistry , medicine , statin , cholesterol , enzyme , biochemistry , simvastatin
Nonsteroidal anti-inflammatory drugs (NSAIDs) cause gastrointestinal damage as one of their side effects in humans and experimental animals. Lipid peroxidation plays an important role in NSAID-induced ulceration. The aim of this study was to investigate the inhibitory effect of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors on the ulceration in small intestines of rats.