Open AccessCombination of telomerase antisense oligonucleotides simultaneously targeting hTR and hTERT produces synergism of inhibition of telomerase activity and growth in human colon cancer cell line
Author(s) -
Xiaohua Fu,
Jiansong Zhang,
Na Zhang,
Zhang Yang-de
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i6.785
Subject(s) - telomerase , telomerase reverse transcriptase , microbiology and biotechnology , transfection , cell growth , cell culture , apoptosis , biology , flow cytometry , cancer research , biochemistry , gene , genetics
To investigate synergism of inhibition of telomerase activity and proliferation of human colon cancer cells by combination of telomerase antisense oligonucleotides (ASODNs) simultaneously targeting human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT) in vitro.