Open AccessLoss of heterozygosity: An independent prognostic factor of colorectal cancer
Author(s) -
Shih Ching Chang,
Jen Kou Lin,
Tzu Chen Lin,
Wen-Yew Liang
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i6.778
Subject(s) - loss of heterozygosity , microsatellite instability , colorectal cancer , carcinogenesis , biology , pathological , rectum , microsatellite , stage (stratigraphy) , pathology , cancer research , medicine , gastroenterology , cancer , oncology , allele , gene , genetics , paleontology
Colorectal cancers result from the accumulation of several distinct genetic alterations. This study was to investigate the frequency and prognostic value of loss of heterozygosity (LOH) and microsatellite instability (MSI) at 14 genetic loci located near or within regions containing important genes implicated in colorectal tumorigenesis.