Open AccessAssociation between polymorphisms in the Toll-like receptor 4, CD14, andCARD15/NOD2and inflammatory bowel disease in the Greek population
Author(s) -
Maria Gazouli,
Gerassimos J. Mantzaris,
Athanassios Kotsinas,
Panayotis Zacharatos,
Efstathios Papalambros,
A Archimandritis,
John Ikonomopoulos,
Vassilis G. Gorgoulis
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i5.681
Subject(s) - nod2 , inflammatory bowel disease , genotype , allele , genotyping , cd14 , allele frequency , immunology , pathogenesis , genotype frequency , biology , tlr4 , medicine , gene , genetics , innate immune system , disease , inflammation , immune system
Crohn's disease (CD) and ulcerative colitis (UC) are multifactorial diseases with a significant genetic background. Apart from CARD15/NOD2 gene, evidence is accumulating that molecules related to the innate immune response such as CD14 or Toll-like receptor 4 (TLR4), are involved in their pathogenesis. In further exploring the genetic background of these diseases, we investigated the variations in the CARD15/NOD2 gene (Arg702Trp, Gly908Arg and Leu1007fsinsC), and polymorphisms in the TLR4 gene (Asp299Gly and Thr399Ile) as well as in the promoter of the CD14 gene (T/C at position -159) in Greek patients with CD and UC.