Open AccessIn vitroresistance to interferon of hepatitis B virus with precore mutation
Author(s) -
Yan Wang,
Lai Wei,
Dong Jiang,
Cong Xu,
Ran Fei,
Jin-Fen Xiao,
Yu Wu
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i5.649
Subject(s) - virology , hepatitis b virus , biology , hbsag , viral replication , transfection , interferon , virus , mutation , recombinant dna , microbiology and biotechnology , cell culture , gene , genetics
Chronic hepatitis B virus (HBV) infection is predominantly treated with interferon alpha (IFN-alpha), which results in an efficient reduction of the viral load only in 20-40% of treated patients. Mutations at HBV precore prevail in different clinical status of HBV infection. The roles of precore mutation in the progression of chronic hepatitis and interferon sensitivity are still unknown. The aim of this study was to explore if there was any relationship between HBV precore mutation and sensitivity to interferon in vitro.