In vitroresistance to interferon of hepatitis B virus with precore mutation | Zendy

Yan Wang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

In vitroresistance to interferon of hepatitis B virus with precore mutation

Author(s) -

Yan Wang

Publication year - 2005

Publication title -

world journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 155

eISSN - 2219-2840

pISSN - 1007-9327

DOI - 10.3748/wjg.v11.i5.649

Subject(s) - virology , hepatitis b virus , biology , hbsag , viral replication , transfection , interferon , virus , mutation , recombinant dna , microbiology and biotechnology , cell culture , gene , genetics

Chronic hepatitis B virus (HBV) infection is predominantly treated with interferon alpha (IFN-alpha), which results in an efficient reduction of the viral load only in 20-40% of treated patients. Mutations at HBV precore prevail in different clinical status of HBV infection. The roles of precore mutation in the progression of chronic hepatitis and interferon sensitivity are still unknown. The aim of this study was to explore if there was any relationship between HBV precore mutation and sensitivity to interferon in vitro.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research