Open AccessHelicobacter pyloriupregulates prion protein expression in gastric mucosa: A possible link to prion disease
Author(s) -
Peter C. Konturek,
Karolina Bazela,
Vitaliy Kukharskyy,
Michael Bauer,
Eckhart G. Hahn,
Detlef Schuppan
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i48.7651
Subject(s) - helicobacter pylori , downregulation and upregulation , gastric mucosa , tumor necrosis factor alpha , biology , inflammation , gastrin , gastritis , stomach , gastrointestinal tract , medicine , immunology , endocrinology , secretion , gene , biochemistry
Pathological prion protein (PrP(sc)) is responsible for the development of transmissible spongiform encephalopathies (TSE). While PrPc enters the organism via the oral route, less data is available to know about its uptake and the role of gastrointestinal inflammation on the expression of prion precursor PrPc, which is constitutively expressed in the gastric mucosa.