Open AccessA novel gain of function mutant in C-kit gene and its tumorigenesis in nude mice
Author(s) -
Chenguang Bai,
Xiaohong Liu,
Qiang Xie,
Fan Feng,
Dalie Ma
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i45.7104
Subject(s) - transfection , microbiology and biotechnology , lipofectamine , biology , cell culture , mutant , clone (java method) , hek 293 cells , stromal cell , carcinogenesis , complementary dna , gene , cancer research , vector (molecular biology) , genetics , recombinant dna
To transfect mutant C-kit cDNA at codon 579 into human embryonic kidney cell line to observe its role in the pathogenesis of gastrointestinal stromal tumor (GIST).