Open AccessDifferential effects of glutamate receptor antagonists on dorsal horn neurons responding to colorectal distension in a neonatal colon irritation rat model
Author(s) -
Chun Lin,
Elie D. Al–Chaer
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i41.6495
Subject(s) - irritation , distension , distal colon , glutamate receptor , medicine , french horn , anesthesia , antagonist , visceral pain , dorsum , receptor , nociception , pharmacology , anatomy , psychology , immunology , pedagogy
To investigate and compare the effects of spinal D-(-)-2-amino-7-phosphonoheptanoic acid (AP-7) and 6-cyano-7-nitroquinoxaline-2,3-dione disodium (CNQX), two glutamate receptor antagonists, on the responses of dorsal horn neurons to colorectal distension (CRD) in adult rats exposed to neonatal colon irritation (CI).