Open AccessPotential effects of L-NAME on alcohol-induced oxidative stress
Author(s) -
Hafize Uzun,
Gönül Şimşek,
Seval Aydın,
Ethem Ünal,
Yesari Karter,
Nermin Yelmen,
Suphi Vehid,
Asl Curgunlu,
Şennur Kaya
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i4.600
Subject(s) - malondialdehyde , oxidative stress , superoxide dismutase , chemistry , glutathione , medicine , nitric oxide synthase , catalase , nitric oxide , ethanol , biochemistry , endocrinology , enzyme
Nitric oxide (NO) is a highly reactive oxidant synthesized from L-arginine by nitric oxide synthase (NOS). NO may cause injury through the generation of potent radicals. Nw- nitro-L-arginine methyl ester (L-NAME) is a non-selective inhibitor of NOS. We aimed to evaluate whether L-NAME treatment had protective effects against oxidative stress in rats intragastrically fed with ethanol during a 4 wk-period.